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Data Availability. All other data supporting the findings of this study are available within the paper and its supplementary information files. The source data underlying Figs 1b, 2b–f, Figs 1, 2h,I, and Supplementary Figs S1-S9, Figs S11-S17, Figs S19,20, Figs S22-S24, Figs S28-S30, Figs S32, Figs S34-S40 are provided as a Source Data file