Published December 15, 2021 | Version v1
Dataset Open

SPAᴴM: the spectrum of approximated hamiltonian matrices representations

  • 1. Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland

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Description

Physics-inspired molecular representations are the cornerstone of similarity-based learning applied to solve chemical problems. Despite their conceptual and mathematical diversity, this class of descriptors shares a common underlying philosophy: they all rely on the molecular information that determines the form of the electronic Schrödinger equation. Existing representations take the most varied forms, from non-linear functions of atom types and positions to atom densities and potential, up to complex quantum chemical objects directly injected into the ML architecture. In this work, we present the Spectrum of Approximated Hamiltonian Matrices (SPAᴴM) as an alternative pathway to construct quantum machine learning representations through leveraging the foundation of the electronic Schrödinger equation itself: the electronic Hamiltonian. As the Hamiltonian encodes all quantum chemical information at once, SPAᴴM representations not only distinguish different molecules and conformations, but also different spin, charge, and electronic states. As a proof of concept, we focus here on efficient SPAᴴM representations built from the eigenvalues of a hierarchy of well-established and readily-evaluated "guess" Hamiltonians. These SPAᴴM representations are particularly compact and efficient for kernel evaluation and their complexity is independent of the number of different atom types in the database

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References

Preprint
A. Fabrizio, K. R. Briling, C. Corminboeuf, Preprint, arXiv:2110.13037 (2021)

Journal reference
A. Fabrizio, K. R. Briling, C. Corminboeuf, Digital Discovery 1, 286-294 (2022), doi: 10.1039/D1DD00050K

Journal reference
A. Fabrizio, K. R. Briling, C. Corminboeuf, Digital Discovery 1, 286-294 (2022)