Published May 31, 2021 | Version v1
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Porous functionalized polymers enable generating and transporting hyperpolarized mixtures of metabolites

  • 1. Univ. Lyon, Centre de RMN à Très Hauts Champs de Lyon, FRE2034 - CNRS/UCBL/ENS de Lyon, 5 rue de la Doua, 69100 Villeurbanne, France.
  • 2. Univ Lyon, CPE Lyon, CNRS, Catalyse, Chimie, Polymères et Procédés, UMR 5265, F-69003, Lyon, France
  • 3. Bruker Biospin, Billerica, Massachusetts 01821, United States
  • 4. Bruker Biospin, 8117 Fallanden, Switzerland
  • 5. Bruker Italia Srl, 20158 Milano, Italy
  • 6. Univ Lyon, INSA Lyon, MATEIS UMR CNRS 5510, Bât. Blaise Pascal, 7 Avenue Jean Capelle, Villeurbanne, France

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Description

Hyperpolarization by dissolution dynamic nuclear polarization (dDNP) has enabled promising applications in spectroscopy and imaging, but remains poorly widespread due to experimental complexity. Broad democratization of dDNP would require remote preparation and distribution of hyperpolarized samples from dedicated facilities. We describe here new hyperpolarizing polymers (HYPOPs) that can generate radical- and contaminant-free hyperpolarized samples within minutes with lifetimes exceeding hours in the solid state. HYPOPs feature tunable macroporous porosity, with porous volumes up to 80% and concentration of nitroxide radicals grafted in the bulk matrix up to 285 μmol g-1. Analytes can be efficiently impregnated as aqueous/alcoholic solutions and hyperpolarized up to P(13C) =25% within 8 min, through the combination of 1H spin diffusion and 1H →13C cross polarization. Solutions of 13C-analytes of biological interest hyperpolarized in HYPOPs display a very long solid-state 13C relaxation times of 5.7 h at 3.8 K, thus prefiguring transportation over long distances.

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References

Preprint (Paper in which the data is discussed)
T. El Darai, S. Cousin, Q. Stern, M. Ceillier, J. Kempf, D. Eshchenko, R. Melzi, M. Schnell, L. Gremillard, A. Bornet, J. Milani, B. Vuichoud, O. Cala, D. Montarnal and S. Jannin, submitted, doi: 10.21203/rs.3.rs-123790/v1